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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461373 / VAT: CZ60461373
Czech Post certified digital mail code: sp4j9ch
Copyright: UCT Prague 2015
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.
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[obsah] => Welcome on the website of the Department of Organic Technology!
The Department of Organic Technology is one of the largest workplaces of the Faculty of Chemical Technology of the University of Chemical Technology in Prague. The institute is rather a specialized workplace.
The Deparment is mainly focused on research in industrial chemistry and process optimization, characterisation of materials' microstructure, a study of reaction kinetics, mechanism and catalysis. An important part of the deparment also belongs to a pharmaceutical engineering.
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[obsah] => The Department of Organic Technology is one of the largest departments of Faculty of Chemical Technology UCT in Prague. The main topics that the department focuses on are classic industrial chemistry, heterogeneous and homogenenous catalysis, and production of pharmaceuticals. The department cooperates with many domestic and foreign universities, institutions and companies. The students are frequently involved in actual research topics in cooperation with these institutions. Therefore, both basic and applied research are conducted. The detailed information about research groups are presented in a separate section.
The department provides a study in various czech bachelor, master and doctoral programmes same as courses for foreign students.
Bachelor degree
The Department of Organic Technology provides a study in three-year programme Chemistry and technology with specialisation Chemical Technology
Master degree
The Department of Organic Technology provides a study in a two-year master programme Chemistry, Technology and Materials with specialisation Chemistry and Chemical Technology for students graduated in a bachelor degree.
Doctoral degree
There is also a possilibity to study a doctoral degree in a studying programmes Chemistry and Chemical Technologies (standard) and Chemistry and Chemical Technologies (double degree).
The lessons and research topics within all three study degrees often correspond to the current projects and industrial cooperation.
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[obsah] => Our research is devided into many fields of chemistry. Main fields represent: Petrochemistry, Catalysis, Characterization of particles, Medicinal chemistry etc...
Laboratory of Medicinal Diagnostic
Group leaders: Kamila Syslová, PhD., Lada Dolejšová Sekerová, PhD.
Topics: Metabolomics; Molecularly imprinted polymers; Separation techniques
Laboratory of Heterogeneous Materials
Group leaders: Assoc. Prof. Pavel Čapek, PhD., Martin Veselý, PhD.
Topics: Microstructure; Transport properties; Mathematical modeling; Heterogeneous catalysis; Microscopy; Spectroscopy
Process Design Lab
Group leader: Assoc. Prof. Jiří Trejbal, PhD.
Topics: Reaction kinetics; Phase equilibria; Catalysis; Distillation & Extraction processes; Chemical reactors modelling
PharmTech Group
Group leader: Prof. Petr Zámostný, PhD.
Topics: Inverse gas chromatography; Interactive mixture; Dissolution rate; Powder rheology
Laboratory of Dermal and Transdermal Delivery
Group leader: Assoc. Prof. Dr. Jarmila Zbytovská
Topics: Dermal and transdermal delivery; Skin permeation enhancers; Nanoformulation processes; Skin barrier and its pathophysiology
Laboratory of Applied Catalysis and Fine Chemicals
Group leaders: Prof. Libor Červený, Assoc. Prof. Eliška Vyskočilová, PhD.
Topics: Heterogeneous & homogeneous catalysis; Hydrogenation/isomerization/oxidation/acid–base reactions; Fine chemicals; Catalyst modification
Technology & Process Optimization
Group leader: Prof. Petr Zámostný, PhD.
Topics: Chemical reaction kinetics; Mathematical modelling; Process optimization; Process control; Steam-cracking
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UCT, Building A, room 77a (secretariat)
Technická 5
166 28 Prague 6 – Dejvice
Phone: +420 220 444 167
E-mail: alena.krivska@vscht.cz
Wher you find us?
The secretariat of the Department of Organic technology is situated on the ground floor of building UCT Prague. The department is located on the left side from entrance to the main hall behind of swing door.
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[obsah] => Our research is devided into many fields of chemistry. Main fields represent: Petrochemistry, Catalysis, Characterization of particles, Medicinal chemistry etc...
Laboratory of Medicinal Diagnostic
Group leaders: Kamila Syslová, PhD., Lada Dolejšová Sekerová, PhD.
Topics: Metabolomics; Molecularly imprinted polymers; Separation techniques
Laboratory of Heterogeneous Materials
Group leaders: Assoc. Prof. Pavel Čapek, PhD., Martin Veselý, PhD.
Topics: Microstructure; Transport properties; Mathematical modeling; Heterogeneous catalysis; Microscopy; Spectroscopy
Process Design Lab
Group leader: Assoc. Prof. Jiří Trejbal, PhD.
Topics: Reaction kinetics; Phase equilibria; Catalysis; Distillation & Extraction processes; Chemical reactors modelling
PharmTech Group
Group leader: Prof. Petr Zámostný, PhD.
Topics: Inverse gas chromatography; Interactive mixture; Dissolution rate; Powder rheology
Laboratory of Dermal and Transdermal Delivery
Group leader: Assoc. Prof. Dr. Jarmila Zbytovská
Topics: Dermal and transdermal delivery; Skin permeation enhancers; Nanoformulation processes; Skin barrier and its pathophysiology
Laboratory of Applied Catalysis and Fine Chemicals
Group leaders: Prof. Libor Červený, Assoc. Prof. Eliška Vyskočilová, PhD.
Topics: Heterogeneous & homogeneous catalysis; Hydrogenation/isomerization/oxidation/acid–base reactions; Fine chemicals; Catalyst modification
Technology & Process Optimization
Group leader: Prof. Petr Zámostný, PhD.
Topics: Chemical reaction kinetics; Mathematical modelling; Process optimization; Process control; Steam-cracking
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[seo_title] => Laboratory of Dermal and Transdermal Drug Delivery
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[obsah] => 
Key Members
- Assoc. Prof. Dr. Jarmila Zbytovská X b
- Kristýna Dvořáková, MSc.
- Aneta Kalvodová, Msc.
- Damla Orhan, Msc.
- Eliška Petrová, Msc.
Group Focus
The skin is one of the largest organs of body, which makes it a great candidate for drug delivery. However, the skin possesses exceptional barrier properties hindering almost every attempt for transdermal or dermal passage of compounds. For this purpose, the Laboratory of dermal and transdermal drug delivery focuses on various ways for the enhancement of drug application via the skin. One such way is the development of various types of nanoparticulate formulations and testing their effect on the drug’s skin permeation behaviour. The next focus in put on the development, characterization and use of novel compounds acting as permeation or penetration enhancers for skin delivery. Another field of interest is to study skin barrier at the molecular level by various biophysical techniques. This also involves the skin pathophysiology and diseases related to impaired skin barrier (psoriasis, atopic dermatitis, skin cancer, and others).
Research topics
- Dermal and transdermal delivery of actives
- Skin permeation enhancers and their modes of action
- Dermal and transdermal nanoformulations and their effect on the skin
- Nanoformulation processes
- Skin barrier and its pathophysiology
- Biophysics of stratum corneum lipid matrix
Franz Diffusion Cells TEWL probe Biox Systems AquaFluxTM AF200
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We apply concept of spectro-microscopy to get insight into this relation by measuring the the same spot on the catalyst using various spectroscopic and microscopic techniques, ideally under in-situ or operando conditions.
We use advanced image and data processing of naturally multimodal data to uncover the nature of the sturcture-activity relation.
Key Members
- Prof. Libor Červený X b
- Assoc. Prof. Eliška Vyskočilová, PhD. X b
- Maria Kotova, PhD. X b
- Iva Paterová, PhD. X b
- Eva Zapletalová, PhD. X b
Group Focus
- Optimization of the preparation and production of chemical specialties (fragrances, drugs, pesticides, etc.)
- Preparation and use of new homogeneous and heterogeneous catalysts
- Processing of biomass into biologically active substances
- Use of CO2 in the field of chemical specialties
- Hydrogenation and dehydrogenation processes in the pharmaceutical and fragrance industry
- Study of the mechanism of heterogeneously catalyzed acid-base reactions
- Design and preparation of catalysts based on hydrotalcites
- Design and preparation of catalysts based on organometallic complexes
Hydrotalcite Ibuprofen structure
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Group focus
The group focuses on heterogeneous materials from two independent views:
- First, we characterize heterogeneous materials (i.e., porous materials, composite materials, catalysts) and determine the 3D microstructure, followed by revealing the relations between the microstructure and mass transport properties such as permeability and diffusivity. These transport parameters are predicted from the 3D microstructure, and the prediction is validated using independent macroscopic measurements in Wicke-Kallenbach diffusion and quasi-stationary permeation cell.
- Second, we focus on the preparation, characterization, and application of novel 2D materials as catalyst support for single metal atoms (Single‑atom Catalysis, SAC) and metal nanoparticles. We aim to reveal the relation between heterogeneous catalyst structure and catalytic activity using both independent ex-situ and in-situ/operando characterization methods.
Key Members
Group Focus:
- Preparation and characterization of solid dispersions of poorly water soluble drugs
- The use of inverse gas chromatography for surface characterization of pharmaceuticals
- Formulation-related effects on drug release rate
- Controlled preparation of interactive powder mixtures
- Development of rapid-disintegrating systems
- Optimization of mixture flow properties
- Mechanical properties of pharmaceutical tablets
- Compaction behavior of mixtures
- Pharmaceutical process cleaning alidation
- Study of process induced disorder in solids
Disolution apparatus SOTAX AT7 SMART Optical microscope NIKON
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Group Focus
- Development of advanced separation tools in the basis of molecularly imprinted polymers (MIP) for isolation of compounds from body tissues and fluids
- Analysis of small molecules in biological matrices for disease diagnostics, pharmacokinetic measurements and validation of experimental medicine results
- Synthesis of new transition metal-based chemotherapeutics for the treatment of cancer disease
The laboratory disposes of modern analytical instruments such as hybrid mass spectrometer LTQ Orbitrap Velos and mass spectrometer with triple quadrupole TSQ Vantage (both Thermo Scientific, USA) for quantification and qualification of analysed substances with a high reliability and accuracy
Key Members
Group Focus
- Laboratory pyrolysis as an experimental model for evaluation of novel/renewable feedstock for industrial steam-cracker
- Study pyrolysis kinetics of individual substances using the experimental and/or mathematical model
- Development of supportive tools for process optimization and control
The publication activity of the group is available HERE. 
Ethylene pyrolysis in ORLEN Unipetrol
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Key Members
- Assoc. Prof. Jiří Trejbal, PhD. X b
- Prof. Josef Pašek
- Assoc. Prof. Bohumír Dvořák, PhD.
- Tomáš Sommer, PhD. X b
- Martin Zapletal, PhD. X b
Group Focus
- Optimization of the current industrial processes worldwide
- Experimental determination of reaction kinetics, reaction and phase equilibria
- Research in distillation or extraction processes
- Modelling of chemical reactors
- Experimental determination of physical-chemical properties of various individuals
As an examples of our work we could present a devolopment of a technological unit for the aniline production in Tosoh, Japan (left figure) and the installation of distillation column for methanol regeneration in VUAB Pharma, Czech Republic (right figure).
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Industrial partners
|
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ORLEN UNIPETROL, a.s. |
AROMA, a.s. |
ZENTIVA GROUP, a.s. |
|
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 |
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ADDICOO GROUP, s.r.o. |
AROMEDICA s.r.o. |
BorsodChem MCHZ, s.r.o. |
|
|
|
|
DEZA, a.s. |
INTERPHARMA PRAHA, a.s. |
Messer Technogas s.r.o. |
|
|
|
|
PENTO, s.r.o. |
SPOLANA, s.r.o. |
SULTRADE Praha spol. s .r.o. |
|
|
|
|
Synthomer a.s. |
ŠKODA AUTO, a.s. |
VUAB PHARMA, a.s. |
Academic partners
|
|
|
|
First Faculty of Medicine
|
Faculty of Science
|
Institute of Physics of the Czech Academy of Sciences |
|
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Institute of Chemical Process Fundamentals of the CAS |
Institute of Organic Chemistry and Biochemistry of the CAS |
Katholieke Universiteit Leuven |
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Slovak University of Technology in Bratislava |
Ultrecht University |
University of Applied Sciences and Arts, Switzerland |
